Department of Psychology, University of Southern California, Los Angeles, California 90089-1061, USA.
Alcohol Clin Exp Res. 2009 Aug;33(8):1476-86. doi: 10.1111/j.1530-0277.2009.00978.x. Epub 2009 May 4.
Major depression and alcohol dependence co-occur within individuals and families to a higher than expected degree. This study investigated whether mood-related drinking motives mediate the association between major depression and alcohol dependence, and what the genetic and environmental bases are for this relationship.
The sample included 5,181 individuals from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, aged 30 and older. Participants completed a clinical interview which assessed lifetime major depression, alcohol dependence, and mood-related drinking motives.
Mood-related drinking motives significantly explained the depression-alcohol dependence relationship at both the phenotypic and familial levels. Results from twin analyses indicated that for both males and females, the familial factors underlying mood-related drinking motives accounted for virtually all of the familial variance that overlaps between depression and alcohol dependence.
The results are consistent with an indirect role for mood-related drinking motives in the etiology of depression and alcohol dependence, and suggest that mood-related drinking motives may be a useful index of vulnerability for these conditions.
重度抑郁症和酒精依赖在个体和家庭中同时出现的比例高于预期。本研究旨在调查情绪相关的饮酒动机是否在重度抑郁症和酒精依赖之间存在关联中起中介作用，以及这种关系的遗传和环境基础是什么。
该样本包括来自弗吉尼亚州成人双生子精神和物质使用障碍研究的 5181 名年龄在 30 岁及以上的个体。参与者完成了一项临床访谈，评估了终生重度抑郁症、酒精依赖和情绪相关的饮酒动机。
情绪相关的饮酒动机在表型和家族水平上都显著解释了抑郁和酒精依赖之间的关系。双胞胎分析的结果表明，对于男性和女性，情绪相关的饮酒动机的家族因素解释了抑郁和酒精依赖之间几乎所有重叠的家族变异。
研究结果与情绪相关的饮酒动机在抑郁和酒精依赖的病因学中起间接作用的观点一致，并表明情绪相关的饮酒动机可能是这些疾病易感性的有用指标。
