Zhang Ling, Yang Ming, Song Yan, Sun Zhongwei, Peng Yi, Qu Kai, Zhu Haibo
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
J Ethnopharmacol. 2009 May 4;123(1):34-9. doi: 10.1016/j.jep.2009.02.033. Epub 2009 Mar 4.
To evaluate the antihypertensive effect of 3,3,5,5-tetramethyl-4-piperidone (TMP), a new compound extracted from Marasmius androsaceus. Besides, the hemodynamic profiles and pertinent mechanism of the compound were explored.
Acute and chronic antihypertensive effects of TMP were examined in spontaneous hypertensive rats (SHRs) and reno-hypertensive rats (two kidneys one clip model, 2K1C). Anesthetized dogs were used to evaluate the hemodynamic effects of TMP. Moreover, the cat nictitating membrane response was used to test the ganglionic blocking property of TMP.
TMP (2.5, 5 and 10mg/kg, p.o.) notably reduced the blood pressure of SHR in 30 min. Two-week administration of TMP (2.5, 5 and 10mg/kg, p.o.) also decreased the blood pressure of 2K1C rats. TMP (30 mg/kg, i.v.) abolished the response of the nictitating membrane induced by preganglionic stimulation. The results of hemodynamic study in anesthetized dogs showed that, except for the reduction in blood pressure and left ventricular work, no other changes were detected. The results of heart rate variability analysis indicated an intact sympathetic-vagal balance after TMP treatment.
TMP is a new antihypertensive compound, and the effect is partially related to ganglionic blocking.
评估从红菇提取的一种新化合物3,3,5,5 - 四甲基 - 4 - 哌啶酮（TMP）的降压作用。此外，还探究了该化合物的血流动力学特征及相关机制。
在自发性高血压大鼠（SHR）和肾性高血压大鼠（双肾单夹模型，2K1C）中检测TMP的急性和慢性降压作用。使用麻醉犬评估TMP的血流动力学效应。此外，利用猫瞬膜反应检测TMP的神经节阻断特性。
TMP（2.5、5和10mg/kg，口服）在30分钟内显著降低SHR的血压。连续两周给予TMP（2.5、5和10mg/kg，口服）也可降低2K1C大鼠的血压。TMP（30mg/kg，静脉注射）消除了节前刺激诱导的瞬膜反应。麻醉犬的血流动力学研究结果表明，除血压和左心室作功降低外，未检测到其他变化。心率变异性分析结果表明，TMP治疗后交感 - 迷走平衡保持完好。
TMP是一种新型降压化合物，其作用部分与神经节阻断有关。
