Dworkin Amy M, Huang Tim H-M, Toland Amanda Ewart
Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
Semin Cancer Biol. 2009 Jun;19(3):165-71. doi: 10.1016/j.semcancer.2009.02.007. Epub 2009 Feb 20.
Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics because of their potential for reversal. Future medical care for breast cancer patients will likely depend upon a better understanding of the roles epigenetic modifications play in carcinogenesis. Here, we discuss the importance of epigenetics in breast cancer detection, prognosis, and therapy with an emphasis on mechanisms and epigenetic contributions to field cancerization effects.
基因组的表观遗传改变，如DNA启动子甲基化和染色质重塑，在肿瘤发生中起着重要作用。最近的研究结果表明，表观遗传修饰是乳腺癌发生的关键因素。由于这些修饰具有可逆性，作为预防保健和治疗的靶点颇具吸引力。未来乳腺癌患者的医疗护理可能取决于对表观遗传修饰在致癌过程中所起作用的更好理解。在此，我们讨论表观遗传学在乳腺癌检测、预后和治疗中的重要性，重点关注其机制以及对场癌化效应的表观遗传贡献。
