Söhngen D, Schneider W
Medizinische Klinik und Poliklinik der Heinrich-Heine Universität Düsseldorf.
Klin Wochenschr. 1991 Jul 22;69(10):419-25. doi: 10.1007/BF01666826.
No generally accepted policy for avoiding HLA-alloimmunization has so far been established. However, several studies suggest that single-donor instead of random-donor transfusions, white cell depletion, UV-radiation of blood products or application of cyclosporine to the recipient may avoid or at least delay alloimmunization. With regard to cost effectiveness, it would be essential to identify patients with the highest risk of developing alloimmunization. For the time being, transfusion of crossmatch-compatible HLA-selected single donor platelets should be restricted to alloimmunized patients, refractory to pooled random donor platelets.
目前尚未建立普遍接受的避免HLA同种免疫的政策。然而，多项研究表明，采用单供者而非随机供者输血、白细胞去除、血液制品紫外线照射或给受者应用环孢素可能避免或至少延迟同种免疫。就成本效益而言，识别发生同种免疫风险最高的患者至关重要。目前，交叉配型相容的HLA选择单供者血小板的输血应仅限于对混合随机供者血小板无效的同种免疫患者。
