通过DNA-二烯-铱（I）杂化催化剂进行的烯丙基胺化反应。
Allylic amination by a DNA-diene-iridium(I) hybrid catalyst.
作者信息
Fournier Pierre, Fiammengo Roberto, Jäschke Andres
机构信息
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, 69120 Heidelberg, Germany.
出版信息
Angew Chem Int Ed Engl. 2009;48(24):4426-9. doi: 10.1002/anie.200900713.
PMID:19431178
Abstract
DNA hybrid catalysis goes organometallic: A DNA strand functionalized with diene ligands forms iridium(I) complexes that can efficiently catalyze an allylic amination in aqueous medium (see scheme). The DNA-based complexes show high stability and activity, and their secondary structure influences the stereoselectivity of the reaction.
摘要
DNA杂化催化走向有机金属化：用二烯配体功能化的DNA链形成铱（I）配合物，该配合物能在水介质中高效催化烯丙基胺化反应（见示意图）。基于DNA的配合物表现出高稳定性和活性，其二级结构影响反应的立体选择性。
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