掺入的H-胸腺嘧啶衰变对细菌的影响。
Effects of Decay of Incorporated H-Thymidine on Bacteria.
作者信息
Person S, Leah Lewis H
出版信息
Biophys J. 1962 Nov;2(6):451-63. doi: 10.1016/s0006-3495(62)86867-2.
The killing efficiency due to the decay of incorporated H(3)-thymidine in three mutants of E. coli strain 15: 15(T-), 15(T-L-), and 15(T-U-) has been determined. This efficiency is comparable to that previously determined by others for P(32) decay. The killing efficiency has been determined as a function of H(3)-thymidine specific activity, storage media and storage temperature. We have observed a latent killing effect that causes lethality under certain conditions. The kinetics of latent killing have been examined at several temperatures. Finally, mutation production induced by H(3)-thymidine decays was shown to occur. The results are consistent with the idea that inactivation and mutations may be caused by a process in the nuclear transmutation that is not associated with beta-particle ionization damage.
已测定了大肠杆菌15菌株的三个突变体15(T-)、15(T-L-)和15(T-U-)中，掺入的H(3)-胸腺嘧啶核苷衰变所导致的杀伤效率。该效率与其他人先前测定的P(32)衰变的杀伤效率相当。已将杀伤效率测定为H(3)-胸腺嘧啶核苷比活度、储存介质和储存温度的函数。我们观察到一种潜在的杀伤效应，在某些条件下会导致致死性。已在几个温度下研究了潜在杀伤的动力学。最后，证明了由H(3)-胸腺嘧啶核苷衰变诱导的突变产生。这些结果与以下观点一致，即失活和突变可能是由与β粒子电离损伤无关的核嬗变过程引起的。
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