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[老年保护剂:特定作用还是应激效应?]

[Geroprotectors: specific action or hormesis?].

作者信息

Vaĭserman A M

出版信息

Adv Gerontol. 2008;21(4):564-9.

Abstract

In recent years, a number of nutrients and chemicals including antioxidants, vitamins, and hormones are widely advertised as "anti-aging" drugs ("geroprotectors"). It is usually believed that life-extending capacity of geroprotectors may be attributed to their specific anti-aging mechanisms, even without solid scientific evidence. Induction of the hormetic adaptive response in stressed organisms could be alternative explanation. The evidence that life-extending effects of anti-aging drugs may be due to hormetic-like response is discussed in this analytic review.

摘要

近年来,包括抗氧化剂、维生素和激素在内的多种营养物质和化学物质被广泛宣传为“抗衰老”药物(“老年保护剂”)。通常认为,即使没有确凿的科学证据,老年保护剂的延长寿命能力可能归因于其特定的抗衰老机制。应激生物体中诱导的应激性适应性反应可能是另一种解释。这篇分析性综述讨论了抗衰老药物的延长寿命作用可能归因于类应激反应的证据。

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