二甲双胍作为一种抗衰老保护剂。
Metformin as a geroprotector.
机构信息
Ghent University, Ghent, Belgium.
出版信息
Rejuvenation Res. 2011 Oct;14(5):469-82. doi: 10.1089/rej.2011.1153. Epub 2011 Sep 1.
PMID:21882902
Abstract
Abstract Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect of metformin and to describe the possible mechanisms behind it.
摘要
摘要 衰老抑制剂是指能够降低衰老速度、从而延长寿命的药物。二甲双胍被描述为一种衰老抑制剂，有几项研究表明二甲双胍可以减缓衰老速度。然而，二甲双胍抗衰老作用的确切机制仍不太明确。本文旨在探讨二甲双胍抗衰老作用的证据，并描述其可能的作用机制。
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