Anisimov V N, Zabezhinskiĭ M A, Popovich I G
Adv Gerontol. 2009;22(2):237-52.
Current approaches to evaluation of efficacy and safety of potential life span extending drugs (geroprotectors) are reviewed in the paper. The methods and protocol of evaluating the effect of pharmacological drugs on aging and life span in mice which have used by the authors are described in details. Principles and criteria of evaluation of degree of evidence the experimental studies in rodents as well as a possibility of extrapolation to humans are discussed.
本文综述了目前评估潜在寿命延长药物（老年保护剂）疗效和安全性的方法。详细描述了作者所采用的评估药物对小鼠衰老和寿命影响的方法及方案。讨论了啮齿动物实验研究证据程度的评估原则和标准，以及外推至人类的可能性。
