Yamshchikov Alexandra V, Oladele Alawode, Leonard Michael K, Blumberg Henry M, Ziegler Thomas R, Tangpricha Vin
Division of Infectious Diseases, Department of Medicine, Emory University-School of Medicine, Atlanta, GA 30303, USA.
South Med J. 2009 Jun;102(6):649-52. doi: 10.1097/SMJ.0b013e3181a5d37e.
Vitamin D regulates calcium homeostasis in the body and may play a major role in regulating immune responses to tuberculosis (TB). Pilot studies suggest that vitamin D supplementation may improve outcomes in pulmonary TB (PTB), but clinical evidence using vitamin D in TB treatment is limited. We present a case of vitamin D deficiency in a woman with refractory drug-susceptible PTB. Antituberculous therapy and the correction of vitamin D deficiency resulted in clinical and microbiologic improvement at month 13 of her treatment. The basis for vitamin D/TB interactions and a brief literature review are discussed. Data from controlled trials are needed to evaluate the efficacy of vitamin D as adjunctive TB therapy.
维生素D调节人体钙稳态，可能在调节对结核病（TB）的免疫反应中起主要作用。初步研究表明，补充维生素D可能改善肺结核（PTB）的治疗效果，但在结核病治疗中使用维生素D的临床证据有限。我们报告一例患有难治性药物敏感型PTB的女性维生素D缺乏病例。抗结核治疗及维生素D缺乏的纠正使她在治疗第13个月时临床和微生物学状况得到改善。本文讨论了维生素D与结核病相互作用的基础并进行简要文献综述。需要来自对照试验的数据来评估维生素D作为辅助结核病治疗的疗效。
