Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
Clin Exp Otorhinolaryngol. 2008 Dec;1(4):217-20. doi: 10.3342/ceo.2008.1.4.217. Epub 2008 Dec 26.
Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%.
喉神经内分泌肿瘤是一组形态学上具有异质性的肿瘤。这种不常见的肿瘤包括四种不同类型的肿瘤。副神经节瘤是最知名的神经起源肿瘤。上皮起源的肿瘤根据分化程度进一步分为高分化癌、中分化癌和低分化癌。喉神经内分泌肿瘤的多种生物学行为使得准确诊断至关重要，因为治疗取决于诊断的准确性。诊断主要基于光镜检查，需要进行免疫组织化学和/或超微结构研究以正确诊断。中分化喉神经内分泌癌的主要治疗方法是手术。应考虑到颈淋巴结转移的高可能性，选择性行颈部治疗。5 年生存率约为 50%，10 年生存率仅为 30%。
