Hauser H, Wolf G, Uranüs S, Klimpfinger M
Department of Surgery, Medical School, Karl Franzens University, Graz, Austria.
Eur J Surg Oncol. 1995 Jun;21(3):297-300. doi: 10.1016/s0748-7983(95)91624-5.
Neuroendocrine cells are present in various organ systems. These widely distributed cells as well as their histogenetically related tumours can produce various peptides and peptide hormones. From 1984 to 1993, 349 neuroendocrine tumours were found among 511,382 histological diagnoses at the Institute of Pathology of the Medical School of the Karl Franzens University in Graz. In 30% carcinoid of the appendix was diagnosed, in 16% carcinoid of the colorectum, in 9% carcinoid of the small intestine and in 2% duodenal carcinoid. Carcinoid of the stomach was detected in 14%. Seven of these cases showed microcarcinoidosis and five of them were combined with an adenocarcinoma. Carcinoid of the oesophagus was present in 1%, neuroendocrine pancreatic tumours in 6%. Neuroendocrine tumours of the bronchial system were found in 12%, medullary thyroid cancer in 5%. In 1% a Merkel-cell tumour was diagnosed. Other more rare localizations of neuroendocrine tumours were the uterus, ovary, breast, testes, epididymis, anal region and the upper respiratory tract.
神经内分泌细胞存在于各种器官系统中。这些广泛分布的细胞及其组织发生相关的肿瘤可产生各种肽和肽类激素。1984年至1993年期间，格拉茨卡尔·弗兰岑斯大学医学院病理研究所511382例组织学诊断中发现了349例神经内分泌肿瘤。其中30%诊断为阑尾类癌，16%为结直肠类癌，9%为小肠类癌，2%为十二指肠类癌。14%检测到胃类癌。这些病例中有7例显示微类癌病，其中5例合并腺癌。1%存在食管类癌，6%为神经内分泌胰腺肿瘤。12%发现支气管系统神经内分泌肿瘤，5%为甲状腺髓样癌。1%诊断为默克尔细胞癌。神经内分泌肿瘤的其他较罕见部位是子宫、卵巢、乳腺、睾丸、附睾、肛门区域和上呼吸道。
