诺丽（Morinda citrifolia）果汁对黄嘌呤氧化酶的抑制作用。

Xanthine oxidase inhibiting effects of noni (Morinda citrifolia) fruit juice.

机构信息

Tahitian Noni International Research and Development, 737 East 1180 South American Fork, Utah 84003, USA.

出版信息

Phytother Res. 2009 Dec;23(12):1790-1. doi: 10.1002/ptr.2842.

PMID:19434757

Abstract

Morinda citrifolia L. (noni), family Rubiaceae, has been used in Polynesia for over 2000 years for its reputed health benefits, one of which is its therapeutic effects on gout (langa e hokotanga hui). However, its healing mechanism has not been elucidated. This study showed that in an in vitro bioassay that Tahitian Noni Juice (TNJ) inhibited xanthine oxidase (XO) concentration dependently. Concentrations of 1, 5 and 10 mg/mL of TNJ inhibited XO by 11%, 113% and 148%, respectively, with an IC50 of 3.8 mg compared with an IC50 of 2.4 microm for allopurinol. Noni fruit juice concentrate (NFJC) also inhibited XO concentration dependently. Concentrations of 1 and 5 mg/mL NFJC inhibited XO in vitro by 184% and 159%, respectively. A 0.1 mg/mL methanol extract (NFJME) from the fractionation of noni fruit puree inhibited XO by 64%. It was elucidated that the noni fruit juice inhibitory effect on XO enzymes is the mechanism by which noni ameliorates gout and gout-like diseases. Further, the results also support the traditional usage of noni in the treatment of gout.

摘要

诺丽果（Morinda citrifolia L.，茜草科）在波利尼西亚地区已被使用了 2000 多年，因其具有多种健康益处而闻名，其中之一是对痛风（langa e hokotanga hui）的治疗作用。然而，其治疗机制尚未阐明。本研究表明，在体外生物测定中，大溪地诺丽果汁（Tahitian Noni Juice，TNJ）可浓度依赖性地抑制黄嘌呤氧化酶（xanthine oxidase，XO）。浓度为 1、5 和 10 mg/mL 的 TNJ 对 XO 的抑制率分别为 11%、113%和 148%，IC50 为 3.8 mg，而别嘌呤醇的 IC50 为 2.4 µm。诺丽果果汁浓缩物（Noni fruit juice concentrate，NFJC）也可浓度依赖性地抑制 XO。浓度为 1 和 5 mg/mL 的 NFJC 对 XO 的体外抑制率分别为 184%和 159%。诺丽果果肉匀浆分离得到的 0.1 mg/mL 甲醇提取物（NFJME）对 XO 的抑制率为 64%。研究结果表明，诺丽果果汁对 XO 酶的抑制作用是其改善痛风和痛风样疾病的机制。此外，这些结果也支持了传统上使用诺丽果治疗痛风的方法。