Palu Afa K, Kim Anne Hirazumi, West Brett J, Deng Shixin, Jensen Jarakae, White Leland
Noni Benefits Research Department, Tahitian Noni International Research Center, 737 East 1180 South, American Fork, UT 84003, USA.
J Ethnopharmacol. 2008 Feb 12;115(3):502-6. doi: 10.1016/j.jep.2007.10.023. Epub 2007 Oct 24.
The aim of this study was to investigate the mechanisms involved in the immunomodulatory effects of Morinda citrifolia L. (noni) in vitro and in vivo in mice. In vitro, Tahitian Noni Juice (TNJ) and Noni fruit juice concentrates (NFJC) (1, 5mg/mL) potently activate cannabinoid 2 (CB2), but inhibit cannabinoid 1 (CB1) receptors in a concentration-dependant manner. In vivo, oral administration of TNJ ad libitum for 16 days decreased the production of IL-4, but increased the production of IFN-gamma. These results suggest that noni modulates the immune system via activating of the CB2 receptors, and suppressing of the IL-4, but increasing the production of IFN-gamma cytokines. It may also exert beneficial immunomodulation effects in conditions involving inadequate immune responses.
本研究的目的是调查海巴戟天（诺丽果）在体外和小鼠体内的免疫调节作用机制。在体外，大溪地诺丽果汁（TNJ）和诺丽果汁浓缩物（NFJC）（1、5mg/mL）能有效激活大麻素2（CB2），但以浓度依赖方式抑制大麻素1（CB1）受体。在体内，随意口服TNJ 16天可降低IL-4的产生，但增加IFN-γ的产生。这些结果表明，诺丽通过激活CB2受体、抑制IL-4但增加IFN-γ细胞因子的产生来调节免疫系统。它在免疫反应不足的情况下也可能发挥有益的免疫调节作用。
