Tahitian Noni International, R&D, American Fork, Utah, USA.
Phytother Res. 2010 Oct;24(10):1437-41. doi: 10.1002/ptr.3150.
Morinda citrifolia L. (Rubiaceae) commonly known as noni, has been used in Polynesia by traditional healers for the treatment of cuts, bruises and wounds. Our objective was to investigate the wound-healing mechanisms of the noni leaf. The investigations of its wound-healing mechanisms were carried out using fresh noni leaf juice (NLJ), noni leaf ethanol extract (NLEE) and its methanol (MFEE) and hexane (HFEE) fractions on the PDGF and A(2A) receptors in vitro and topically in mice. Fresh noni leaf juice showed significant affinity to PDGF receptors, and displayed 166% binding inhibition of the ligand binding to its receptors, while at the same concentration, it only had 7% inhibition of the ligand binding to the A(2A) receptors. NLEE, HFEE and MFEE showed significant affinity to A(2A) receptors, concentration dependently, with IC(50) values of 34.1, 42.9 and 86.7 μg/mL, respectively. However, MFEE significantly increased wound closure and reduced the half closure time in mice with a CT(50) of 5.4 ± 0.2 days compared with control (p < 0.05). These results suggest that noni leaf significantly accelerated wound healing in mice via its ligand binding to the PDGF and A(2A) receptors as its probable mechanisms of wound-healing and also support its traditional usage for wound-healing in Polynesia.
巴戟天（茜草科）俗称诺丽，已在波利尼西亚传统治疗师中用于治疗伤口、瘀伤和创伤。我们的目的是研究诺丽叶的愈合机制。使用新鲜诺丽叶汁（NLJ）、诺丽叶乙醇提取物（NLEE）及其甲醇（MFEE）和己烷（HFEE）馏分在体外和小鼠的伤口局部研究其愈合机制。新鲜诺丽叶汁对 PDGF 受体具有显著的亲和力，并显示出配体与受体结合的 166%的结合抑制，而在相同浓度下，它仅对配体与 A(2A)受体的结合具有 7%的抑制作用。NLEE、HFEE 和 MFEE 对 A(2A)受体具有显著的亲和力，呈浓度依赖性，IC50 值分别为 34.1、42.9 和 86.7μg/mL。然而，MFEE 显著增加了伤口闭合，并将小鼠的半闭合时间减少至 CT50 为 5.4±0.2 天，与对照组相比（p<0.05）。这些结果表明，诺丽叶通过配体与 PDGF 和 A(2A)受体的结合显著加速了小鼠的伤口愈合，这可能是其伤口愈合的机制，并支持其在波利尼西亚用于伤口愈合的传统用途。
