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桑白皮提取物的抗痉挛和血管扩张活性是通过阻断电压依赖性钙通道来介导的。

Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels.

机构信息

Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan.

出版信息

BMC Complement Altern Med. 2010 Jan 13;10:2. doi: 10.1186/1472-6882-10-2.

DOI:10.1186/1472-6882-10-2
PMID:20070879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2829485/
Abstract

BACKGROUND

Morinda citrifolia (Noni) is an edible plant with wide range of medicinal uses. It occurs exclusively in tropical climate zone from India through Southeast Asia and Australia to Eastern Polynesia and Hawaii. The objective of this study was to explore the possible mode(s) of action for its antispasmodic, vasodilator and cardio-suppressant effects to rationalize its medicinal use in gut and cardiovascular disorders.

METHODS

Isolated tissue preparations such as, rabbit jejunum, rat and rabbit aorta and guinea pig atria were used to test the antispasmodic and cardiovascular relaxant effects and the possible mode of action(s) of the 70% aqueous-ethanolic extract of Morinda citrifolia roots (Mc.Cr).

RESULTS

The Mc.Cr produced a concentration-dependent relaxation of spontaneous and high K(+) induced contractions in isolated rabbit jejunum preparations. It also caused right ward shift in the concentration response curves of Ca(++), similar to that of verapamil. In guinea-pig right atria, Mc.Cr caused inhibition of both atrial force and rate of spontaneous contractions. In rabbit thoracic aortic preparations, Mc.Cr also suppressed contractions induced by phenylephrine (1.0 μM) in normal- Ca(++) and Ca(++)-free kreb solutions and by high K(+), similar to that of verapamil. In rat thoracic aortic preparations, Mc.Cr also relaxed the phenylephrine (1.0 μM)-induced contractions. The vasodilatory responses were not altered in the presence of L-NAME (0.1 mM) or atropine (1.0 μM) and removal of endothelium.

CONCLUSIONS

These results suggest that the spasmolytic and vasodilator effects of Mc.Cr root extract are mediated possibly through blockade of voltage-dependent calcium channels and release of intracellular calcium, which may explain the medicinal use of Morinda citrifolia in diarrhea and hypertension. However, more detailed studies are required to assess the safety and efficacy of this plant.

摘要

背景

诺丽果（Morinda citrifolia，Noni）是一种具有广泛药用用途的可食用植物。它仅存在于热带气候带，从印度经东南亚和澳大利亚到东波利尼西亚和夏威夷。本研究的目的是探索其抗痉挛、血管舒张和心脏抑制作用的可能作用模式，以合理化其在肠道和心血管疾病中的药用用途。

方法

使用分离的组织制剂，如兔空肠、大鼠和兔主动脉以及豚鼠心房，测试 Morinda citrifolia 根的 70%水-乙醇提取物（Mc.Cr）的抗痉挛和心血管舒张作用及其可能的作用模式。

结果

Mc.Cr 对兔空肠自发和高 K(+)诱导收缩的浓度依赖性舒张。它还导致 Ca(++)浓度反应曲线向右移动，类似于维拉帕米。在豚鼠右心房，Mc.Cr 引起心房力和自发性收缩率的抑制。在兔胸主动脉制剂中，Mc.Cr 还抑制了去甲肾上腺素（1.0 μM）在正常 Ca(++)和无 Ca(++)Kreb 溶液以及高 K(+)诱导的收缩，类似于维拉帕米。在大鼠胸主动脉制剂中，Mc.Cr 还舒张了去甲肾上腺素（1.0 μM）诱导的收缩。在存在 L-NAME（0.1 mM）或阿托品（1.0 μM）和去除内皮的情况下，血管舒张反应没有改变。

结论

这些结果表明，Mc.Cr 根提取物的解痉和血管舒张作用可能是通过阻断电压依赖性钙通道和释放细胞内钙介导的，这可以解释诺丽果在腹泻和高血压中的药用用途。然而，需要进行更详细的研究来评估这种植物的安全性和疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/51e349251e06/1472-6882-10-2-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/1ea28b102a49/1472-6882-10-2-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/6956166d5e2f/1472-6882-10-2-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/78fa396ead01/1472-6882-10-2-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/352ed79fabab/1472-6882-10-2-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/97b18fad1e21/1472-6882-10-2-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/00303efb1408/1472-6882-10-2-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/51e349251e06/1472-6882-10-2-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/1ea28b102a49/1472-6882-10-2-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/8b1b68d05cfb/1472-6882-10-2-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/6956166d5e2f/1472-6882-10-2-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/78fa396ead01/1472-6882-10-2-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/352ed79fabab/1472-6882-10-2-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/97b18fad1e21/1472-6882-10-2-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/00303efb1408/1472-6882-10-2-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6757/2829485/51e349251e06/1472-6882-10-2-8.jpg

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