Kosten T A, Marby D W, Nestler E J
Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.
Life Sci. 1991;49(24):PL201-6. doi: 10.1016/0024-3205(91)90490-3.
Previous research shows that buprenorphine (BUP), a mixed opioid agonist-antagonist, reduces cocaine use in humans and suppresses cocaine self-administration in monkeys. The present study found that BUP reduces cocaine's ability to condition a place preference in rats. Compared to vehicle treated rats, rats treated with BUP 2 times/day for 2 weeks spent significantly less time in the cocaine conditioned place compared to their respective saline trained controls. No conditioned place preference was shown for BUP alone. These results further implicate a role for the opioid system in cocaine use and stress the importance of differentiating chronic vs. acute opioid effects.
先前的研究表明，丁丙诺啡（BUP），一种混合阿片类激动剂-拮抗剂，可减少人类的可卡因使用，并抑制猴子的可卡因自我给药行为。本研究发现，丁丙诺啡可降低可卡因在大鼠中形成位置偏好的能力。与接受赋形剂处理的大鼠相比，每天接受2次丁丙诺啡处理、持续2周的大鼠，与各自的生理盐水训练对照组相比，在可卡因条件化位置停留的时间明显更少。单独使用丁丙诺啡未显示出条件性位置偏好。这些结果进一步表明阿片系统在可卡因使用中发挥作用，并强调区分慢性与急性阿片类效应的重要性。
