制备非常稳定且具有生物相容性的荧光二氧化硅纳米颗粒的新方法。
New method to prepare very stable and biocompatible fluorescent silica nanoparticles.
作者信息
Ha Shin-Woo, Camalier Corinne E, Beck George R, Lee Jin-Kyu
机构信息
Department of Chemistry, Seoul National University, Seoul, Korea.
出版信息
Chem Commun (Camb). 2009 May 28(20):2881-3. doi: 10.1039/b902195g. Epub 2009 Apr 6.
Abstract
A new synthetic method has been developed to prepare fluorescent silica nanoparticles without employing isothiocyanated dye molecules and (3-aminopropyl)triethoxysilane (APS) for the thiourea linkage formation; the resulting fluorescent silica nanoparticles show excellent photochemical, thermal and pH stabilities and a good biocompatibility with over 85% viability from various cell types.
摘要
已开发出一种新的合成方法来制备荧光二氧化硅纳米颗粒，该方法无需使用异硫氰酸酯染料分子和（3-氨丙基）三乙氧基硅烷（APS）来形成硫脲键；所得的荧光二氧化硅纳米颗粒表现出优异的光化学、热和pH稳定性，以及与多种细胞类型的良好生物相容性，细胞活力超过85%。
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本文引用的文献
1
Cellular uptake and cytotoxicity of silica nanotubes.
Nano Lett. 2008 Aug;8(8):2150-4. doi: 10.1021/nl0802741. Epub 2008 Jul 12.
2
Synthesis of carbohydrate-conjugated nanoparticles and quantum dots.
Langmuir. 2008 Jun 17;24(12):6215-9. doi: 10.1021/la800066g. Epub 2008 May 15.
3
Core-shell silica nanoparticles as fluorescent labels for nanomedicine.
J Biomed Opt. 2007 Nov-Dec;12(6):064007. doi: 10.1117/1.2823149.
4
Intracellular delivery of core-shell fluorescent silica nanoparticles.
Biomaterials. 2008 Apr;29(10):1526-32. doi: 10.1016/j.biomaterials.2007.11.025. Epub 2007 Dec 21.
5
Synthesis, characterization, and biological applications of multifluorescent silica nanoparticles.
Anal Chem. 2007 Sep 1;79(17):6507-14. doi: 10.1021/ac070394d. Epub 2007 Jul 21.
6
Specific targeting, cell sorting, and bioimaging with smart magnetic silica core-shell nanomaterials.
Small. 2006 Feb;2(2):209-15. doi: 10.1002/smll.200500360.
7
In vitro toxicity of silica nanoparticles in human lung cancer cells.
Toxicol Appl Pharmacol. 2006 Dec 15;217(3):252-9. doi: 10.1016/j.taap.2006.10.004. Epub 2006 Oct 6.
8
Toxicity and tissue distribution of magnetic nanoparticles in mice.
Toxicol Sci. 2006 Jan;89(1):338-47. doi: 10.1093/toxsci/kfj027. Epub 2005 Oct 19.
9
Cellular fate of a modular DNA delivery system mediated by silica nanoparticles.
Biotechnol Prog. 2005 Mar-Apr;21(2):532-7. doi: 10.1021/bp049648w.
10
Bright and stable core-shell fluorescent silica nanoparticles.
Nano Lett. 2005 Jan;5(1):113-7. doi: 10.1021/nl0482478.
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