Earhart Christopher, Jana Nikhil R, Erathodiyil Nandanan, Ying Jackie Y
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
Langmuir. 2008 Jun 17;24(12):6215-9. doi: 10.1021/la800066g. Epub 2008 May 15.
Nanoparticle-based probes are emerging as alternatives to molecular probes due to their various advantages, such as bright and tunable optical property, enhanced chemical and photochemical stability, and ease of introduction of multifunctionality. This work presents a simple and general approach for functionalizing various nanoparticle systems for use as glycobiological probes. Silica-coated nanoparticles of Ag, Fe3O4, and ZnS-CdSe were synthesized and functionalized with dextran. The resulting 10-40-nm-sized particles were robust, water-soluble, colloidally stable, and biochemically active.
基于纳米颗粒的探针因其具有多种优势，如明亮且可调节的光学性质、增强的化学和光化学稳定性以及易于引入多功能性等，正逐渐成为分子探针的替代品。这项工作提出了一种简单且通用的方法，用于对各种纳米颗粒系统进行功能化，以用作糖生物学探针。合成了包覆二氧化硅的银、四氧化三铁和硫化锌 - 硒化镉纳米颗粒，并用葡聚糖进行功能化。所得的尺寸为10 - 40纳米的颗粒坚固、水溶性好、胶体稳定且具有生物化学活性。
