Ferreira Erika Goulart Veloso, Maestá Izildinha, Michelin Odair Carlito, de Paula Regina Célia Callile, Consonni Marcos, Rudge Marilza Vieira Cunha
Trophoblastic Diseases Center, Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University, Botucatu, SP, Brazil.
J Reprod Med. 2009 Apr;54(4):239-44.
To assess quality of life (QoL) and psychological aspects in patients with gestational trophoblastic disease (GTD).
This cross-sectional self-report study was conducted among 54 women. Validated question-naires assessed QoL (WHO-QOL-bref), symptoms of depression (Beck Depression Inventory [BDI]) and anxiety (State-Trait Anxiety Inventory [STAI]).
Most patients rated overall QoL as good (44.44%) and were satisfied with their health status (42.59%). Mean QoL domain score was lowest for psychologic health (53.86 +/- 21.46) and highest for social relationships (65.74 +/- 22.41). BDI mean was 15.81 +/- 11.15, indicating dysphoria. STAI means were 46 +/- 6.46 for trait-anxiety and 43.72 +/- 4.23 for state-anxiety, both evidencing medium-high anxiety. Among employed patients, environment domain mean was the highest (p = 0.024). Presence of children resulted in lowest means for physical health (p = 0.041) and environment (p= 0.045). Patients desiring children showed significantly higher means for physical health (p = 0.004), psychological health (p = 0.021) and environment (p = 0.003). Chemotherapy had no significant influence on QoL (p > 0.05).
This study evidenced psychological impact on GTD patients, suggesting specialized care centers should provide psychological interventions during treatment and follow-up of GTD patients, highlighting the importance of a multidisciplinary approach.
评估妊娠滋养细胞疾病（GTD）患者的生活质量（QoL）和心理状况。
本横断面自我报告研究对54名女性进行。使用经过验证的问卷评估生活质量（世界卫生组织生活质量简表[WHO-QOL-bref]）、抑郁症状（贝克抑郁量表[BDI]）和焦虑症状（状态-特质焦虑量表[STAI]）。
大多数患者将总体生活质量评为良好（44.44%），并对自身健康状况感到满意（42.59%）。生活质量领域平均得分中心理健康最低（53.86±21.46），社会关系最高（65.74±22.41）。BDI平均分为15.81±11.15，表明存在烦躁不安。STAI特质焦虑平均分为46±6.46，状态焦虑平均分为43.72±4.23，均表明存在中度至高度焦虑。在就业患者中，环境领域平均分最高（p = 0.024）。有孩子的患者身体健康（p = 0.041）和环境（p = 0.045）平均分最低。想要孩子的患者在身体健康（p = 0.004）、心理健康（p = 0.021）和环境（p = 0.003）方面的平均分显著更高。化疗对生活质量无显著影响（p>0.05）。
本研究证明了对GTD患者的心理影响，表明专业护理中心应在GTD患者的治疗和随访期间提供心理干预，突出了多学科方法的重要性。
