鹿蜱病毒脑炎致死病例。
Fatal case of deer tick virus encephalitis.
作者信息
Tavakoli Norma P, Wang Heng, Dupuis Michelle, Hull Rene, Ebel Gregory D, Gilmore Emily J, Faust Phyllis L
机构信息
Wadsworth Center, New York State Department of Health and the Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA.
出版信息
N Engl J Med. 2009 May 14;360(20):2099-107. doi: 10.1056/NEJMoa0806326.
Abstract
Deer tick virus is related to Powassan virus, a tickborne encephalitis virus. A 62-year-old man presented with a meningoencephalitis syndrome and eventually died. Analyses of tissue samples obtained during surgery and at autopsy revealed a widespread necrotizing meningoencephalitis. Nucleic acid was extracted from formalin-fixed tissue, and the presence of deer tick virus was verified on a flavivirus-specific polymerase-chain-reaction (PCR) assay, followed by sequence confirmation. Immunohistochemical analysis with antisera specific for deer tick virus identified numerous immunoreactive neurons, with prominent involvement of large neurons in the brain stem, cerebellum, basal ganglia, thalamus, and spinal cord. This case demonstrates that deer tick virus can be a cause of fatal encephalitis.
摘要
鹿蜱病毒与波瓦桑病毒有关，波瓦桑病毒是一种蜱传脑炎病毒。一名62岁男性出现脑膜脑炎综合征，最终死亡。对手术和尸检时获取的组织样本进行分析，发现广泛的坏死性脑膜脑炎。从福尔马林固定的组织中提取核酸，并通过黄病毒特异性聚合酶链反应（PCR）检测证实了鹿蜱病毒的存在，随后进行了序列确认。用针对鹿蜱病毒的抗血清进行免疫组织化学分析，发现大量免疫反应性神经元，脑干、小脑、基底神经节、丘脑和脊髓中的大神经元受累明显。该病例表明，鹿蜱病毒可导致致命性脑炎。
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