Duffner P K, Cohen M E
State University of New York, Buffalo.
Neurol Clin. 1991 May;9(2):479-95.
Survivals of children with brain tumors have increased over the past 20 years owing to advances in surgery, radiation, and, most recently, chemotherapy. Unfortunately, central nervous system therapy, particularly radiation, may be associated with the development of dementia and learning disabilities, leukoencephalopathy, endocrinopathies, and oncogenesis. Recognition of these long-term effects of therapy is important as some are amenable to treatment and others may be prevented by modification of current treatment regimens.
在过去20年里，由于外科手术、放疗以及最近的化疗取得进展，脑肿瘤患儿的生存率有所提高。不幸的是，中枢神经系统治疗，尤其是放疗，可能与痴呆、学习障碍、白质脑病、内分泌疾病以及肿瘤发生有关。认识到这些治疗的长期影响很重要，因为有些影响可以治疗，而其他影响可能通过修改当前治疗方案来预防。
