Micheli V, Ricci C
Quad Sclavo Diagn. 1983 Mar;19(1):1-37.
Purine metabolism has been much investigated in human erythrocytes, both for the interest focused on this peculiar cell biochemistry, and four purine pathological implications in man. Most mammalian red blood cells lack de novo purine synthesis, and are completely dependent on base salvage pathway for their purine nucleotide requirement. Besides, human erythrocyte is devoid of some purine interconversion enzymes, thus becoming dependent on external supply of bases and nucleosides, particularly the adenylic ones. Red blood cell purine metabolism is very active, owing to its great need for nucleotides, and seems to aim greatly at the preservation of synthesized nucleotides against catabolic events. Available data on purine enzyme kinetic parameters and regulation, substrate and product cellular concentration and uptake are reviewed.
由于对这种特殊细胞生物化学的关注以及嘌呤在人类中的四种病理影响，嘌呤代谢在人类红细胞中得到了广泛研究。大多数哺乳动物红细胞缺乏嘌呤从头合成，其嘌呤核苷酸需求完全依赖于碱基补救途径。此外，人类红细胞缺乏一些嘌呤相互转化酶，因此依赖于碱基和核苷的外部供应，尤其是腺苷酸。红细胞嘌呤代谢非常活跃，因为它对核苷酸有很大需求，并且似乎很大程度上旨在保护合成的核苷酸免受分解代谢事件的影响。本文综述了关于嘌呤酶动力学参数和调节、底物和产物细胞浓度及摄取的现有数据。
