[皮质醇对家兔腺苷酸环化酶系统状态的影响]
[Effect of cortisol on the state of adenyl cyclase system in rabbits].
作者信息
Speranskaia N V, Ozerova I N, Chernysheva N P, Gerasimova E N
出版信息
Vopr Med Khim. 1976 Nov-Dec;22(6):746-9.
Content of 3',5'-cycloAMP was estimated in rabbit blood plasma and urine; activities of adenylcyclase and phosphodiesterase were determined in liver tissue, adipose tissue and adrenal glands within 5, 24 and 48 hrs after hydrocortisone administration. Concentration of 3',5'-cycloAMP was found to be increased 4-6-fold in plasma and urine after the hormone administration. Cortisol was shown to increase also the activity of adenylcyclase and phosphodiesterase in liver tissue within 5 hrs and in adipose tissue--within 24 hrs and 48 hrs after the administration. In adrenal glands hydrocortisone caused an inhibitory effect on the adenylcyclase activity at early steps of the experiment.
对兔血浆和尿液中的3',5'-环磷酸腺苷含量进行了测定；在给予氢化可的松后5小时、24小时和48小时，测定了肝脏组织、脂肪组织和肾上腺中腺苷酸环化酶和磷酸二酯酶的活性。发现给予该激素后，血浆和尿液中3',5'-环磷酸腺苷的浓度增加了4至6倍。还显示，皮质醇在给药后5小时可增加肝脏组织中腺苷酸环化酶和磷酸二酯酶的活性，在24小时和48小时可增加脂肪组织中的活性。在实验早期阶段，氢化可的松对肾上腺中的腺苷酸环化酶活性产生抑制作用。
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