[长期给予促肾上腺皮质激素（ACTH）或皮质醇后大鼠不同组织中腺苷酸环化酶和鸟苷酸环化酶活性的变化]
[Changes in the activity of adenylate- and guanylate cyclase in different rat tissues after chronic administration of ACTH or cortisol].
作者信息
Gorshkova T V, Smirnova N B, Afinogenova S A
出版信息
Biokhimiia. 1988 Apr;53(4):626-36.
The state of adenylate and guanylate cyclases in the adrenals, suprarenal fat and ventricular myocardium of the rat was studied under conditions of chronic administration of ACTH or cortisol. By the end of ACTH injections the weight of the adrenals and the DNA content in them increased 6 and 3 times, respectively; both parameters showed a gradual increase. The corticosteroid level in the blood changed throughout the experiment. The changes in the DNA content in the adrenals and in the corticosteroid level in the blood were oppositely directed. This was paralleled with cyclic changes in the basal and stimulated activities of adenylate and guanylate cyclases occurring with a periodicity of 15 days. The peaks of the cyclase activity preceded the increase in the DNA content. Similar cyclic changes in the enzyme activity were observed in the adipose tissue and myocardium. It was supposed that periodic changes in the cyclase activity are the main prerequisites for the growth and replication of cells under conditions of changed hormonal status of the organism.
在长期给予促肾上腺皮质激素（ACTH）或皮质醇的条件下，研究了大鼠肾上腺、肾上腺脂肪和心室心肌中腺苷酸环化酶和鸟苷酸环化酶的状态。到ACTH注射结束时，肾上腺重量及其DNA含量分别增加了6倍和3倍；这两个参数均呈逐渐增加。在整个实验过程中，血液中的皮质类固醇水平发生了变化。肾上腺中DNA含量的变化与血液中皮质类固醇水平的变化方向相反。这与腺苷酸环化酶和鸟苷酸环化酶的基础活性和刺激活性以15天为周期的周期性变化平行。环化酶活性的峰值先于DNA含量的增加。在脂肪组织和心肌中也观察到了酶活性的类似周期性变化。据推测，在机体激素状态改变的情况下，环化酶活性的周期性变化是细胞生长和复制的主要前提条件。
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