欧洲越橘及其多酚对人内皮细胞中血管紧张素转换酶活性的影响。

Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells.

作者信息

Persson Ingrid A-L, Persson Karin, Andersson Rolf G G

机构信息

Department of Medical and Health, Division of Drug Research/Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden.

出版信息

J Agric Food Chem. 2009 Jun 10;57(11):4626-9. doi: 10.1021/jf900128s.

DOI:10.1021/jf900128s

PMID:19441816

Abstract

This study investigates if the connection between Vaccinium myrtillus and angiotensin-converting enzyme (ACE) might be an explanation of the pharmacological effects on circulation. Cultured endothelial cells from human umbilical veins were incubated with bilberry 25E extract. The main anthocyanidins combined in myrtillin chloride and separately in cyanidin, delphinidin, and malvidin, respectively, were examined concerning their effects on ACE. After 10 min of incubation with bilberry 25E, a significant, dose-dependent inhibition of ACE activity was seen, and after incubation with myrtillin chloride a significant inhibition was seen. No effect was seen with the anthocyanidins. The effect seems to be dependent on this specific mixture of anthocyanins in the bilberry. V. myrtillus may thus have the potential to prevent and protect against cardiovascular diseases.

摘要

本研究调查了欧洲越橘与血管紧张素转换酶（ACE）之间的联系是否可以解释其对循环系统的药理作用。将人脐静脉培养的内皮细胞与越橘25E提取物一起孵育。分别检测了氯化越橘苷中结合的主要花青素以及矢车菊素、飞燕草素和锦葵色素各自对ACE的影响。用越橘25E孵育10分钟后，观察到ACE活性受到显著的剂量依赖性抑制，用氯化越橘苷孵育后也观察到显著抑制。花青素未显示出作用。这种作用似乎取决于越橘中花青素的这种特定混合物。因此，欧洲越橘可能具有预防和抵御心血管疾病的潜力。