Department of Drug Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jednosci 8, 41-200 Sosnowiec, Poland.
Department of General and Inorganic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland.
Molecules. 2020 Nov 16;25(22):5343. doi: 10.3390/molecules25225343.
Polyphenols have recently gained popularity among the general public as products and diets classified as healthy and containing naturally occurring phenols. Many polyphenolic extracts are available on the market as dietary supplements, functional foods, or cosmetics, taking advantage of clients' desire to live a healthier and longer life. However, due to the difficulty of discovering the in vivo functions of polyphenols, most of the research focuses on in vitro studies. In this review, we focused on the cardioprotective activity of different polyphenols as possible candidates for use in cardiovascular disease therapy and for improving the quality of life of patients. Thus, the studies, which were mainly based on endothelial cells, aortic cells, and some in vivo studies, were analyzed. Based on the reviewed articles, polyphenols have a few points of action, including inhibition of acetylcholinesterase, decrease in reactive oxygen species production and endothelial tube formation, stimulation of acetylcholine-induced endothelium-derived mediator release, and others, which lead to their cardio- and/or vasoprotective effects on endothelial cells. The obtained results suggest positive effects of polyphenols, but more long-term in vivo studies demonstrating effects on mechanism of action, sensitivity, and specificity or efficacy are needed before legal health claims can be made.
多酚最近作为健康产品和饮食受到大众欢迎，因为它们含有天然存在的酚类物质。许多多酚提取物以膳食补充剂、功能性食品或化妆品的形式在市场上销售，利用客户希望过上更健康、更长寿的生活的愿望。然而，由于发现多酚体内功能的困难，大多数研究都集中在体外研究上。在这篇综述中，我们重点关注不同多酚的心脏保护活性，因为它们可能是心血管疾病治疗和提高患者生活质量的候选药物。因此，分析了主要基于内皮细胞、主动脉细胞和一些体内研究的研究。根据综述文章，多酚有几个作用点，包括抑制乙酰胆碱酯酶、减少活性氧的产生和内皮管形成、刺激乙酰胆碱诱导的内皮细胞衍生介质释放等，从而对内皮细胞产生心脏和/或血管保护作用。这些结果表明多酚具有积极的作用，但在提出合法的健康声明之前，还需要进行更多的长期体内研究，以证明对作用机制、敏感性、特异性或疗效的影响。
