Han Chong, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2009 Jun 10;131(22):7532-3. doi: 10.1021/ja902046m.
An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired beta-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool for C(sp(3))-C(sp(2)) bond formation.
已开发出一种高效的钯催化方法,用于仲烷基卤化锌与多种芳基溴化物和活性芳基氯化物的Negishi偶联反应。由新型联芳基二烷基膦配体CPhos组成的钯催化剂相对于不希望发生的β-氢消除速率,有效地提高了还原消除步骤的速率。广泛的底物范围以及所需仲偶联产物与不需要的伯偶联产物的优异比例,使得该方法成为形成C(sp(3))-C(sp(2))键的强大而可靠的工具。