Department of Obstetrics and Gynecology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Fertil Steril. 2010 Jul;94(2):485-8. doi: 10.1016/j.fertnstert.2009.03.082. Epub 2009 May 13.
To assess the time to spontaneous ongoing pregnancy after a previous miscarriage in subfertile couples.
A prospective cohort study.
The study was conducted in 38 fertility centers in the Netherlands.
PATIENT(S): Subfertile couples who miscarried after completing their basic fertility work-up.
INTERVENTION(S): Expectant management after a miscarriage.
MAIN OUTCOME MEASURE(S): Spontaneous ongoing pregnancy.
RESULT(S): We included 5,663 subfertile couples, of which 1,098 (19%) conceived spontaneously. Among these 1,098 couples, 199 (18%) miscarried and these couples were included in the present study. Follow-up was completed for 171 couples, of which 95 conceived again within 24 months of follow-up. Of these 95 pregnancies, 86 (91%) were ongoing. The cumulative spontaneous ongoing pregnancy rate (PR) after 24 months was 70% (95% confidence interval [CI] 59%-81%).
CONCLUSION(S): Subfertile couples, who experience a treatment-independent pregnancy resulting in a miscarriage, have very good prospects of a spontaneous ongoing pregnancy in the near future. This information is useful in counseling couples who had a miscarriage after a previous period of subfertility.
评估不孕夫妇上次流产后自发持续妊娠的时间。
前瞻性队列研究。
该研究在荷兰的 38 家生育中心进行。
完成基本生育检查后流产的不孕夫妇。
流产后期待治疗。
自发持续妊娠。
我们纳入了 5663 对不孕夫妇，其中 1098 对（19%）自然受孕。在这 1098 对夫妇中，有 199 对（18%）自然流产，这些夫妇被纳入本研究。对 171 对夫妇进行了随访，其中 95 对在随访后 24 个月内再次怀孕。这 95 例妊娠中，86 例（91%）持续妊娠。24 个月后自发持续妊娠率（PR）为 70%（95%置信区间 59%-81%）。
经历了无需治疗即可怀孕导致流产的不孕夫妇，在不久的将来有很好的自发持续妊娠的前景。这一信息对曾经历过一段时间不孕而后流产的夫妇的咨询很有用。
