Förster Matthias, Bolzinger Marie-Alexandrine, Fessi Hatem, Briançon Stephanie
Université de Lyon, F-69008 Lyon, France; Université Lyon 1, ISPB, Faculté de Pharmacie, CNRS, UMR 5007, LAGEP, F-69622, Villeurbanne, France.
Eur J Dermatol. 2009 Jul-Aug;19(4):309-23. doi: 10.1684/ejd.2009.0676. Epub 2009 May 14.
Percutaneous penetration/permeation is a useful tool for obtaining qualitative and/or quantitative information on the amount of a drug, a cosmetic substance, or any chemical that may enter a skin compartment or the systemic circulation of the human body for pharmaceutical or cosmetic purposes, or for toxicological studies. In the latter case, the extent entering can then be taken into consideration in order to calculate the margin of safety using the NOAEL (No Observed Adverse Effect Level) of an appropriate repeated dose toxicity study with the respective substance. This paper is a short overview of various aspects of skin penetration/permeation of drugs or cosmetic agents. The literature reports numerous studies on skin structure and skin properties influencing drug/cosmetic agent permeation profiles and kinetic parameters. The extensive research concerning the skin structure for determining the key parameters of the penetration/permeation process is therefore described first. Mathematical models of the skin absorption process for a drug are then discussed. Finally new developments in pharmaceutical and cosmetic fields to enhance drug permeation or to modify the stratum corneum structure are considered.
经皮渗透是一种有用的工具，可用于获取有关药物、化妆品成分或任何可能出于制药、化妆品目的或毒理学研究而进入人体皮肤隔室或体循环的化学物质的定性和/或定量信息。在后一种情况下，可以考虑进入的程度，以便使用相应物质的适当重复剂量毒性研究的无观察到有害作用水平（NOAEL）来计算安全边际。本文简要概述了药物或化妆品的皮肤渗透的各个方面。文献报道了许多关于影响药物/化妆品渗透曲线和动力学参数的皮肤结构和皮肤特性的研究。因此，首先描述了关于确定渗透/渗透过程关键参数的皮肤结构的广泛研究。然后讨论了药物皮肤吸收过程的数学模型。最后，考虑了制药和化妆品领域中增强药物渗透或改变角质层结构的新进展。
