Costa Raquel, Costa Lima Sofia A, Gameiro Paula, Reis Salette
LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.
Antioxidants (Basel). 2021 Aug 28;10(9):1376. doi: 10.3390/antiox10091376.
Flavonoids are one of the vital classes of natural polyphenolic compounds abundantly found in plants. Due to their wide range of therapeutic properties, which include antioxidant, anti-inflammatory, photoprotective, and depigmentation effects, flavonoids have been demonstrated to be promising agents in the treatment of several skin disorders. However, their lipophilic nature and poor water solubility invariably lead to limited oral bioavailability. In addition, they are rapidly degraded and metabolized in the human body, hindering their potential contribution to the prevention and treatment of many disorders. Thus, to overcome these challenges, several cutaneous delivery systems have been extensively studied. Topical drug delivery besides offering an alternative administration route also ensures a sustained release of the active compound at the desired site of action. Incorporation into lipid or polymer-based nanoparticles appears to be a highly effective approach for cutaneous delivery of flavonoids with good encapsulation potential and reduced toxicity. This review focuses on currently available formulations used to administer either topically or systemically different classes of flavonoids in the skin, highlighting their potential application as therapeutic and preventive agents.
黄酮类化合物是植物中大量存在的重要天然多酚类化合物之一。由于其具有广泛的治疗特性，包括抗氧化、抗炎、光保护和色素沉着抑制作用，黄酮类化合物已被证明是治疗多种皮肤疾病的有前景的药物。然而，它们的亲脂性和较差的水溶性总是导致口服生物利用度有限。此外，它们在人体中会迅速降解和代谢，阻碍了它们对许多疾病预防和治疗的潜在贡献。因此，为了克服这些挑战，人们对几种皮肤给药系统进行了广泛研究。局部给药除了提供另一种给药途径外，还能确保活性化合物在所需作用部位持续释放。将其掺入脂质或聚合物基纳米颗粒似乎是一种非常有效的皮肤给药黄酮类化合物的方法，具有良好的包封潜力和降低的毒性。本综述重点关注目前用于局部或全身给药不同类黄酮的制剂，强调它们作为治疗和预防药物的潜在应用。
