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人参皂苷Rf通过抑制黑素细胞和人皮肤中的CREB/MITF途径的抗黑素生成特性。

Anti-melanogenic property of ginsenoside Rf from via inhibition of CREB/MITF pathway in melanocytes and human skin.

作者信息

Lee Ha-Ri, Jung Joon Min, Seo Ji-Yeon, Chang Sung Eun, Song Youngsup

机构信息

Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.

Asan Institute for Life Sciences, Asan Medical Center, Republic of Korea.

出版信息

J Ginseng Res. 2021 Sep;45(5):555-564. doi: 10.1016/j.jgr.2020.11.003. Epub 2020 Dec 9.

DOI:10.1016/j.jgr.2020.11.003
PMID:34803425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8587488/
Abstract

BACKGROUND

Ginsenosides of are used to enhance skin health and beauty. The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from as a new anti-pigmentation agent.

METHODS

The anti-melanogenic effects of Rf were explored. The transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated human skin.

RESULTS

Rf significantly inhibited Forskolin (FSK) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by FSK or CREB-regulated transcription coactivator 3 (CRTC3) overexpression. Increased CREB phosphorylation and protein kinase A (PKA) activity induced by FSK were also mitigated in the presence of Rf.

CONCLUSION

Rf can be used as a reliable anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway.

摘要

背景

人参皂苷用于促进皮肤健康与美丽。本研究旨在探讨人参皂苷Rf作为一种新型抗色素沉着剂的潜在用途。

方法

探究Rf的抗黑色素生成作用。在黑素细胞和紫外线照射的人皮肤中评估环磷酸腺苷（cAMP）反应元件结合蛋白（CREB）的转录活性以及酪氨酸酶、小眼畸形相关转录因子（MITF）和酪氨酸酶相关蛋白（Tyrps）的表达水平。

结果

Rf显著抑制福斯高林（FSK）或紫外线刺激的黑色素生成。相应地，细胞酪氨酸酶活性以及MITF、酪氨酸酶和Tyrps的水平均下调。此外，Rf抑制了由FSK或CREB调节的转录共激活因子3（CRTC3）过表达所刺激的MITF启动子活性。在存在Rf的情况下，FSK诱导的CREB磷酸化增加和蛋白激酶A（PKA）活性也得到缓解。

结论

Rf可作为一种可靠的抗色素沉着剂，通过抑制CREB/MITF途径具有科学证实且可重复的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/2ff5265327c3/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/3d9a6bab82dd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/ba02017a89ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/e705a927e2a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/25f1e0fbcc0e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/44f2eb6fb0c0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/0c40c1a4b7da/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/ae91d37e7f1e/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/2ff5265327c3/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/3d9a6bab82dd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/ba02017a89ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/e705a927e2a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/25f1e0fbcc0e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/44f2eb6fb0c0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/0c40c1a4b7da/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/ae91d37e7f1e/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d665/8587488/2ff5265327c3/figs2.jpg

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