Arimoto S, Hayatsu H
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Mutat Res. 1991 Sep-Oct;250(1-2):161-7. doi: 10.1016/0027-5107(91)90172-k.
Direct-acting mutagens to Salmonella typhimurium TA98 were found to be formed from heterocyclic amines on exposure to near-ultraviolet light in the presence of N-nitrosodialkylamines. We have isolated the mutagenic photoproduct formed from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and N-nitrosodimethylamine, and the product was identified as 3-methyl-2-nitroimidazo[4,5-f]quinoline (IQ(NO2]. The yield of IQ(NO2) from IQ was estimated to be 17%. Similar light-dependent activation of IQ was noted with 4 different nitrosodialkylamines other than nitrosodimethylamine. Furthermore, MeIQ and MeIQx were also activated with nitrosamine and light. These reactions represent an example of interaction between 2 different classes of mutagens.
在存在N-亚硝基二烷基胺的情况下，杂环胺在近紫外光照射下会形成对鼠伤寒沙门氏菌TA98有直接作用的诱变剂。我们已分离出由2-氨基-3-甲基咪唑并[4,5-f]喹啉（IQ）和N-亚硝基二甲胺形成的诱变光产物，该产物被鉴定为3-甲基-2-硝基咪唑并[4,5-f]喹啉（IQ(NO2]）。IQ生成IQ(NO2)的产率估计为17%。除了N-亚硝基二甲胺外，用其他4种不同的亚硝基二烷基胺也观察到了类似的IQ光依赖性活化。此外，MeIQ和MeIQx也能被亚硝胺和光活化。这些反应代表了两类不同诱变剂之间相互作用的一个例子。
