Hirose M, Wakabayashi K, Grivas S, De Flora S, Arakawa N, Nagao M, Sugimura T
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
Carcinogenesis. 1990 May;11(5):869-71. doi: 10.1093/carcin/11.5.869.
A direct-acting mutagen to Salmonella typhimurium TA98 was found to be formed by exposing 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in acetone to sunlight for 60 min. The direct-acting mutagen in the irradiated sample was purified by HPLC and identified as 3,4-dimethyl-2-nitroimidazo-[4,5-f]quinoline (NO2-MeIQ). The yield of NO2-MeIQ from MeIQ was estimated to be 0.3%.
发现将丙酮中的2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉（MeIQ）暴露于阳光下60分钟可形成一种对鼠伤寒沙门氏菌TA98有直接诱变作用的物质。通过高效液相色谱法对辐照样品中的直接诱变剂进行纯化，并鉴定为3,4-二甲基-2-硝基咪唑并[4,5-f]喹啉（NO2-MeIQ）。MeIQ生成NO2-MeIQ的产率估计为0.3%。
