Tamura Katsumi, Yoshikawa Kyosan, Ishikawa Hiroyuki, Hasebe Mitsuhiko, Tsuji Hiroshi, Yanagi Tsuyoshi, Suzuki Kazutoshi, Kubo Atsushi, Tsujii Hirohiko
Clinical Diagnosis Section, Research Center, Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba-ken, Japan.
Anticancer Res. 2009 May;29(5):1507-14.
The aim of this study was to assess the feasibility of MET-PET as an evaluation method of the therapeutic effect of carbon ion beam radiotherapy.
Twenty-four choroidal melanoma patients who were treated with a carbon ion beam underwent at least three MET-PET scans before and after therapy. The uptake was visually and semiquantitatively evaluated on the basis of the tumor-to-brain ratio (TBR).
The accumulation was significantly decreased at 6 months or more after therapy and disappeared in 50% of the patients at 12 months after therapy. The baseline TBR, 1, 6, 12 and 24 months after therapy averaged 1.88+/-0.65, 1.73+/-0.52, 1.08+/-0.42, 0.67+/-0.27 and 0.65+/-0.30, respectively. TBR was significantly decreased at 6 months or more after therapy.
MET-PET may be an alternative method for evaluating the effect of radiotherapy.
