Frech Stefanie, Hörmann Karl, Riedel Frank, Götte Karl
Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany.
Anticancer Res. 2009 May;29(5):1675-9.
In head and neck squamous cell carcinoma (HNSCC), metastatic dissemination to regional lymph nodes serves as a major prognostic indicator for incipient disease progression and constitutes the guideline for subsequent therapeutic strategies. In this study, whether intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) might be a predictive indicator to the risk of lymph node metastasis was investigated.
Tumour lymph vessels in fresh frozen sections of 105 head and neck cancer were quantified by immunostaining for the lymphatic endothelial marker LYVE-1. These results underwent correlation with the nodal status of the patient.
There was a significant relationship between a high IT LVD and nodal metastasis (N+) (p=0.049, Mann-Whitney test). Analysed separately by anatomic regions, a significant correlation was only shown in oral carcinoma (p=0.032, Mann-Whitney test). Intratumoral LVD was lower compared to peritumoral LVD. Logistic regression, however, showed that the only predictive parameter for the nodal status was the localisation of the primary tumour but not LVD.
This study confirmed that IT LVD is low in HNSCC. In this group of tumours there was a significant correlation between IT LVD and nodal involvement.
在头颈部鳞状细胞癌（HNSCC）中，区域淋巴结转移是疾病早期进展的主要预后指标，也是后续治疗策略的指导依据。本研究旨在探讨肿瘤内（IT）和肿瘤周围（PT）淋巴管密度（LVD）是否可作为淋巴结转移风险的预测指标。
对105例头颈部癌新鲜冰冻切片中的肿瘤淋巴管进行免疫染色，用淋巴管内皮标志物LYVE-1进行定量分析。将这些结果与患者的淋巴结状态进行相关性分析。
肿瘤内高LVD与淋巴结转移（N+）之间存在显著相关性（p=0.049，Mann-Whitney检验）。按解剖区域分别分析，仅在口腔癌中显示出显著相关性（p=0.032，Mann-Whitney检验）。肿瘤内LVD低于肿瘤周围LVD。然而，逻辑回归分析表明，淋巴结状态的唯一预测参数是原发肿瘤的位置，而非LVD。
本研究证实HNSCC中肿瘤内LVD较低。在这组肿瘤中，肿瘤内LVD与淋巴结受累之间存在显著相关性。
