Lindsey J, McGill N I, Lindsey L A, Green D K, Cooke H J
MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K.
Mutat Res. 1991 Jan;256(1):45-8. doi: 10.1016/0921-8734(91)90032-7.
Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.
通过测定端粒涂片的长度以及TTAGGG重复序列的相对量，对21名年龄在0至92岁之间的人类受试者皮肤细胞中的端粒DNA进行了定量分析。结果发现，端粒长度和端粒重复序列的数量均随年龄增长而显著减少。此前曾推测端粒损耗是细胞衰老的一个原因。
