第三代抗癫痫药物：作用机制、药代动力学及相互作用
Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.
作者信息
Luszczki Jarogniew J
机构信息
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland.
出版信息
Pharmacol Rep. 2009 Mar-Apr;61(2):197-216. doi: 10.1016/s1734-1140(09)70024-6.
This review briefly summarizes the information on the molecular mechanisms of action, pharmacokinetic profiles and drug interactions of novel (third-generation) antiepileptic drugs, including brivaracetam, carabersat, carisbamate, DP-valproic acid, eslicarbazepine, fluorofelbamate, fosphenytoin, ganaxolone, lacosamide, losigamone, pregabalin, remacemide, retigabine, rufinamide, safinamide, seletracetam, soretolide, stiripentol, talampanel, and valrocemide. These novel antiepileptic drugs undergo intensive clinical investigations to assess their efficacy and usefulness in the treatment of patients with refractory epilepsy.
本综述简要总结了新型（第三代）抗癫痫药物的作用分子机制、药代动力学特征及药物相互作用的相关信息，这些药物包括布瓦西坦、卡雷西坦、卡立普多、双丙戊酸、依斯利卡西平、氟非氨酯、磷苯妥英、加奈索酮、拉科酰胺、洛西加莫、普瑞巴林、瑞马西胺、瑞替加滨、卢非酰胺、沙芬酰胺、司来西坦、索雷托利德、司替戊醇、他仑帕奈和缬酪胺。这些新型抗癫痫药物正在进行深入的临床研究，以评估它们在治疗难治性癫痫患者中的疗效和实用性。
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