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尼日利亚贝宁城感染艾滋病毒患者中的贫血患病率。

Prevalence of anaemia among HIV-infected patients in Benin City, Nigeria.

作者信息

Omoregie R, Omokaro E U, Palmer O, Ogefere H O, Egbeobauwaye A, Adeghe J E, Osakue S I, Ihemeje V

机构信息

School of Medical Laboratory Sciences, University of Benin Teaching Hospital, P.M.B. 1111, Benin City, Edo State, Nigeria.

出版信息

Tanzan J Health Res. 2009 Jan;11(1):1-4. doi: 10.4314/thrb.v11i1.43242.

Abstract

The aim of this study was to use the World Health Organization (WHO) definition of anaemia to determine prevalence of anaemia among human immunodeficiency virus (HIV)-infected patients on the highly active antiretroviral therapy (HAART) and those that are HAART naive. Haemoglobin concentration was measured in 457 HIV patients consisting of 217 patients on HAART (86 males and 131 females) and 240 HAART naive patients (106 males and 134 females). According to WHO criteria, anaemia was defined as a haemoglobin concentration below 12g/dl in women and below 13g/dl in men. The anaemic HIV patients were further categorized according to WHO/ACTG anaemia toxicity grades. An overall anaemia prevalence of 60.61% was observed. The prevalence of anaemia was significantly higher among HAART naive patients (69.17%) than in HIV patients on HAART (51.15%) (P < 0.001). The prevalence of anaemia differ significantly (P < 0.05) between males and females of HAART naive patients with males (76.42%) having higher prevalence than females (63.43%). The WHO/ACTG categorization showed the same pattern between HIV patients on HAART and those that were HAART naive. Conclusively, the overall prevalence of anaemia was 60.61% among HIV patients. HAART naive patients have higher prevalence as well as males in this group. The WHO definition of anaemia is recommended as this will give the true prevalence of anaemia and allow for policy and interventions to address it.

摘要

本研究的目的是使用世界卫生组织(WHO)对贫血的定义,来确定接受高效抗逆转录病毒治疗(HAART)的人类免疫缺陷病毒(HIV)感染患者以及未接受过HAART治疗的患者中的贫血患病率。对457名HIV患者进行了血红蛋白浓度测量,其中包括217名接受HAART治疗的患者(86名男性和131名女性)以及240名未接受过HAART治疗的患者(106名男性和134名女性)。根据WHO标准,贫血定义为女性血红蛋白浓度低于12g/dl,男性低于13g/dl。贫血的HIV患者根据WHO/ACTG贫血毒性分级进一步分类。观察到总体贫血患病率为60.61%。未接受过HAART治疗的患者中贫血患病率(69.17%)显著高于接受HAART治疗的HIV患者(51.15%)(P<0.001)。未接受过HAART治疗的患者中,男性(76.42%)和女性(63.43%)的贫血患病率差异显著(P<0.05),男性患病率高于女性。WHO/ACTG分类在接受HAART治疗的HIV患者和未接受过HAART治疗的患者中显示出相同的模式。总之,HIV患者中贫血的总体患病率为60.61%。未接受过HAART治疗的患者以及该组中的男性患病率更高。建议采用WHO对贫血的定义,因为这将给出贫血的真实患病率,并有助于制定政策和采取干预措施来解决这一问题。

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