Cheng C Y, Pickler R H
Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
ScientificWorldJournal. 2014 Jan 22;2014:652630. doi: 10.1155/2014/652630. eCollection 2014.
Stress and fatigue are common complaints of pregnant and postpartum women as is depression. These symptoms may be related to immunomodulation. However, few studies have examined these relationships. The aim of this study was to examine the relationships among stress, fatigue, depression, and cytokines as markers of immune modulation in prenatal and postpartum women. Women completed questionnaires and gave blood samples during late pregnancy and again at 4-6 weeks postpartum. Blood was analyzed for cytokines as measures of immune modulation. Stress, fatigue, and depression were experienced at moderately high levels, with higher levels of fatigue and depression in the postpartum but higher stress in the prenatal period. Levels of several cytokines were increased in the postpartum over the prenatal period. Stress and depression were related in the prenatal period and stress, depression, and fatigue were related in the postpartum. While various cytokines were related to each other in both periods, only stress was related to MIP-1β, a cytokine that may be important for childbirth processes. More studies, especially longitudinal and interventional studies, are needed to increase our knowledge about etiology, patterns, symptoms, factors, and management of maternal distress. The search for reliable biomarkers for at-risk mothers remains a priority.
压力和疲劳是孕妇和产后女性常见的主诉，抑郁也是如此。这些症状可能与免疫调节有关。然而，很少有研究探讨这些关系。本研究的目的是探讨压力、疲劳、抑郁和细胞因子之间的关系，这些细胞因子是产前和产后女性免疫调节的标志物。女性在妊娠晚期和产后4至6周再次完成问卷调查并采集血样。分析血液中的细胞因子作为免疫调节的指标。压力、疲劳和抑郁的程度中等偏高，产后疲劳和抑郁程度较高，但产前压力较高。与产前相比，产后几种细胞因子的水平有所升高。产前压力与抑郁有关，产后压力、抑郁和疲劳有关。虽然两个时期各种细胞因子之间相互关联，但只有压力与MIP-1β相关，MIP-1β是一种可能对分娩过程很重要的细胞因子。需要更多的研究，尤其是纵向研究和干预性研究，以增加我们对孕产妇痛苦的病因、模式、症状、因素和管理的了解。寻找高危母亲的可靠生物标志物仍然是一个优先事项。
