Lu Xiaoling, Wang Yuping, Zhang Zesheng
Key Laboratory of Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
Eur J Pharmacol. 2009 Aug 1;615(1-3):223-7. doi: 10.1016/j.ejphar.2009.04.064. Epub 2009 May 14.
We investigated the radioprotective activity of betalains from red beets in mice irradiated by a (60)Co gamma (gamma) ray (6.0 Gy, at a dose of 1.5 Gy min(-1)). Mice were randomly divided into five groups, namely the control group and four experimental groups which were given one of four concentrations of betalains from red beets (0, 5, 20 and 80 mg/kg, equivalent to betanin) for 30 days. The four experimental groups of mice were then exposed to the (60)Co gamma-rays and were given betalains from red beets for a further 3 days. The number of white blood cells, karyota of the femur and the number of micronuclei in polychromatophilic erythrocytes of bone marrow in mice were determined. The activity of superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, spleen index and thymus index were also determined. The results indicate that the administration of betalains from red beets is radioprotective in mice irradiated by (60)Co in vivo. The underlying mechanism remains unclear but appears to be mediated by the antioxidant activity of the betalains from red beets and modulation of the immune system.
我们研究了红甜菜中甜菜色素对受（60）Coγ射线（6.0 Gy，剂量率为1.5 Gy min⁻¹）照射的小鼠的辐射防护活性。将小鼠随机分为五组，即对照组和四个实验组，四个实验组分别给予四种浓度的红甜菜甜菜色素（0、5、20和80 mg/kg，相当于甜菜红），持续30天。然后，四个实验组的小鼠接受（60）Coγ射线照射，并再给予3天红甜菜甜菜色素。测定小鼠的白细胞数量、股骨细胞数量以及骨髓嗜多染红细胞中的微核数量。还测定了超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、丙二醛、脾脏指数和胸腺指数的活性。结果表明，在体内给予红甜菜甜菜色素对受（60）Co照射的小鼠具有辐射防护作用。其潜在机制尚不清楚，但似乎是由红甜菜甜菜色素的抗氧化活性和免疫系统调节介导的。
