Borroni Elena M, Buracchi Chiara, Savino Benedetta, Pasqualini Fabio, Russo Remo C, Nebuloni Manuela, Bonecchi Raffaella, Mantovani Alberto, Locati Massimo
Laboratory of Leukocyte Biology, Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, Italy.
Methods Enzymol. 2009;460:231-43. doi: 10.1016/S0076-6879(09)05211-2.
Chemokines play a major role in the induction of inflammatory reactions and development of an appropriate immune response by coordinating leukocyte recruitment. The appropriate control of the chemokine system involves several chemokine decoy receptors, with distinct specificity and tissue distribution, defined as nonactivating chemokine receptors able to bind the ligands and target them to degradation. The best-characterized representative of these receptors is D6, which is located on lymphatic endothelium and controls most inflammatory CC chemokines. Here we will discuss the expression and regulation of D6 during challenge with the pathogen, and its role in dampening inflammation in tissues and draining lymph nodes and in the organization of a protective immune response.
趋化因子通过协调白细胞募集，在诱导炎症反应和发展适当的免疫反应中发挥主要作用。趋化因子系统的适当调控涉及几种趋化因子诱饵受体，它们具有不同的特异性和组织分布，被定义为能够结合配体并使其降解的非激活型趋化因子受体。这些受体中研究最深入的代表是D6，它位于淋巴管内皮细胞上，可调控大多数炎性CC趋化因子。在此，我们将讨论病原体攻击期间D6的表达与调控，及其在减轻组织和引流淋巴结炎症以及组织保护性免疫反应中的作用。
