微波辐射加速布朗斯特酸催化的吡咯衍生物的纳扎罗夫环化反应。

Brønsted acid-catalyzed Nazarov cyclization of pyrrole derivatives accelerated by microwave irradiation.

作者信息

Bachu Prabhakar, Akiyama Takahiko

机构信息

Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan.

出版信息

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3764-6. doi: 10.1016/j.bmcl.2009.04.109. Epub 2009 May 3.

DOI:10.1016/j.bmcl.2009.04.109

PMID:19447615

Abstract

The Brønsted acid-catalyzed Nazarov cyclization of pyrrole derivatives was developed. Microwave irradiation accelerated the Nazarov cyclization significantly at 40 degrees C to give cyclopenta[b]pyrrole derivatives in excellent yields with high trans selectivity.

摘要

开发了布朗斯特酸催化的吡咯衍生物的纳扎罗夫环化反应。微波辐射在40℃下显著加速了纳扎罗夫环化反应，以优异的产率和高反式选择性得到环戊并[b]吡咯衍生物。