铁催化、微波促进一锅法通过级联苄基化-环化反应合成 9-取代呫吨。
Iron-catalyzed, microwave-promoted, one-pot synthesis of 9-substituted xanthenes by a cascade benzylation-cyclization process.
机构信息
Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
出版信息
Org Lett. 2010 Jan 1;12(1):100-3. doi: 10.1021/ol902489a.
PMID:19938841
Abstract
An efficient iron-catalyzed, microwave-promoted cascade benzylation-cyclization of phenols is reported. Benzyl acetates, benzyl bromides, and benzyl carbonates are suitable benzylating reagents. The reactions proceed to afford both 9-aryl and 9-alkyl xanthene derivatives in good to high yields using FeCl(3) as the catalyst under MW irradiation conditions.
摘要
报道了一种高效的铁催化、微波促进的酚类化合物的级联苄基化-环化反应。乙酸苄酯、溴化苄和碳酸苄酯是合适的苄基化试剂。在 MW 辐射条件下，以三氯化铁为催化剂，该反应以良好至高产率得到了 9-芳基和 9-烷基呫吨衍生物。
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