二氯醋酸钠对一名线粒体脑肌病伴乳酸血症和卒中样发作（MELAS）患者视幻觉和听幻觉的治疗效果
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.
作者信息
Saijo T, Naito E, Ito M, Takeda E, Hashimoto T, Kuroda Y
机构信息
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
出版信息
Neuropediatrics. 1991 Aug;22(3):166-7. doi: 10.1055/s-2008-1071436.
PMID:1944824
Abstract
We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual and auditory hallucinations. His blood and cerebrospinal fluid lactate levels were remarkably elevated. Sodium dichloroacetate was administered orally at doses of 12.5 to 100 mg/kg/day. On normalization of the lactate levels, the hallucinations disappeared.
摘要
我们报告了一例患有线粒体肌病、脑病、乳酸性酸中毒和类卒中样发作的患者，该患者出现了视幻觉和听幻觉。他的血液和脑脊液乳酸水平显著升高。口服二氯醋酸钠，剂量为12.5至100毫克/千克/天。随着乳酸水平恢复正常，幻觉消失。
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