Yang Q, Moroji T, Takamatsu Y, Hagino Y, Okuwa M
Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, Japan.
Neuropeptides. 1991 Jun;19(2):77-90. doi: 10.1016/0143-4179(91)90136-7.
The effects of intraperitoneally (IP) injected phencyclidine (phencyclohexyl piperidine; PCP) on the metabolism of dopamine (DA) and cholecystokinin-like immunoreactivity (CCK-LI) in the rat brain were investigated in connection with PCP-induced behavioral changes. The predominant behavior change elicited by 2.5 mg/kg PCP was locomotion, while with higher doses (5 and 10 mg/kg) sniffing, swaying and falling were observed in addition to the enhanced locomotor activity. Backpedaling and rotation were observed in 10 mg/kg PCP-treated rats. IP injection of PCP caused a dose-related increase in the levels of DA and 3,4-dihydroxy-phenylacetic acid (DOPAC) in the medial frontal cortex (MFC) and anterior cingulate cortex (ant.CC) without any changes in the nucleus accumbens (NAc) or striatum. CCK-LI in the MFC, ant.CC and NAc was decreased in a dose-dependent manner following IP injection of PCP. These findings support the evidence that PCP selectively activates the mesocortical DA systems. Furthermore, our results indicate a functional relationship between the mesocortical DA neurons and intrinsic CCK containing cortical neurons, and the change in the activity of the intrinsic CCK-containing cortical neurons in these two areas, perhaps due to an alteration in DA transmission, might be involved in behavioral changes after PCP injection.
研究了腹腔注射苯环己哌啶（phencyclohexyl piperidine；PCP）对大鼠脑内多巴胺（DA）代谢及胆囊收缩素样免疫反应性（CCK-LI）的影响，并探讨其与PCP诱导的行为变化之间的关系。2.5mg/kg的PCP引起的主要行为变化是运动，而较高剂量（5和10mg/kg）时，除运动活动增强外，还观察到嗅探、摇晃和跌倒。在10mg/kg PCP处理的大鼠中观察到倒退和旋转。腹腔注射PCP导致内侧额叶皮质（MFC）和前扣带回皮质（ant.CC）中DA和3,4-二羟基苯乙酸（DOPAC）水平呈剂量依赖性增加，而伏隔核（NAc）或纹状体无任何变化。腹腔注射PCP后，MFC、ant.CC和NAc中的CCK-LI呈剂量依赖性降低。这些发现支持了PCP选择性激活中脑皮质DA系统的证据。此外，我们的结果表明中脑皮质DA神经元与含CCK的皮质固有神经元之间存在功能关系，这两个区域中含CCK的皮质固有神经元的活性变化，可能是由于DA传递的改变，可能与PCP注射后的行为变化有关。
