Uchida Kentaroo, Urabe Ken, Naruse Kouji, Ogawa Zensuke, Mabuchi Kiyoshi, Itoman Moritoshi
Department of Biomedical Engineering, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan.
Exp Anim. 2009 Apr;58(2):181-7. doi: 10.1538/expanim.58.181.
Recent studies have focused on the association between primary osteoarthritis and dyslipidemia. STR/Ort mice have unique characteristics including osteoarthritis and hyperlipidemia, and may be a useful model for investigating the effect of dyslipidemia on the underlying mechanism of primary osteoarthritis. However, little is known about the hyperlipidemic properties of STR/Ort mice. In this study we investigated hyperlipidemia and lipotoxicity in STR/Ort mice. STR/Ort mice have human hyperlipidemic patient-like symptoms such as hypercholesteremia, hypertriglyceridemia, hyperinsulinemia, insulin resistance, dysregulation of NEFA, and low serum adiponectin. Excess triglyceride accumulation in the liver of STR/Ort mice was not observed even when they exhibited hyperinsulinemia. This information may be useful for researchers investigating lipid metabolism and primary osteoarthritis using STR/Ort mice.
最近的研究聚焦于原发性骨关节炎与血脂异常之间的关联。STR/Ort小鼠具有包括骨关节炎和高脂血症在内的独特特征，可能是用于研究血脂异常对原发性骨关节炎潜在机制影响的有用模型。然而，关于STR/Ort小鼠的高脂血症特性知之甚少。在本研究中，我们调查了STR/Ort小鼠的高脂血症和脂毒性。STR/Ort小鼠具有类似人类高脂血症患者的症状，如高胆固醇血症、高甘油三酯血症、高胰岛素血症、胰岛素抵抗、游离脂肪酸（NEFA）失调以及血清脂联素水平低。即使STR/Ort小鼠表现出高胰岛素血症，也未观察到其肝脏中甘油三酯过度积累。这些信息可能对使用STR/Ort小鼠研究脂质代谢和原发性骨关节炎的研究人员有用。
