白细胞介素-17A直接抑制辅助性T细胞1（TH1细胞），从而抑制肠道炎症的发展。 - Suppr

Suppr

超能文献

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation.

作者信息

Awasthi Amit, Kuchroo Vijay K

机构信息

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Nat Immunol. 2009 Jun;10(6):568-70. doi: 10.1038/ni0609-568.

DOI:10.1038/ni0609-568

PMID:19448657

Abstract

摘要

相似文献

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation.

Nat Immunol. 2009 Jun;10(6):568-70. doi: 10.1038/ni0609-568.

A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

Nat Immunol. 2009 Jun;10(6):603-9. doi: 10.1038/ni.1736.

Role of innate lymphoid cells in chronic colitis during anti-IL-17A therapy.

Sci Rep. 2020 Jan 15;10(1):297. doi: 10.1038/s41598-019-57233-w.

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

Gastroenterology. 2008 Aug;135(2):552-67. doi: 10.1053/j.gastro.2008.04.037. Epub 2008 May 7.

Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon.

Inflamm Bowel Dis. 2012 Feb;18(2):333-43. doi: 10.1002/ibd.21772. Epub 2011 May 25.

IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.

Eur J Immunol. 2010 Sep;40(9):2423-36. doi: 10.1002/eji.200939764.

IL-4 exacerbates disease in a Th1 cell transfer model of colitis.

J Immunol. 2001 Feb 15;166(4):2793-800. doi: 10.4049/jimmunol.166.4.2793.

IL-17/IFN-γ interactions regulate intestinal inflammation in TNBS-induced acute colitis.

J Interferon Cytokine Res. 2012 Nov;32(11):548-56. doi: 10.1089/jir.2012.0030. Epub 2012 Oct 2.

Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.

Eur J Immunol. 2010 Sep;40(9):2409-22. doi: 10.1002/eji.201040379.

Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut.

Gastroenterology. 2009 Jun;136(7):2270-9. doi: 10.1053/j.gastro.2009.02.049.

引用本文的文献

Secukinumab-induced Crohn's disease in a psoriasis patient: a case report highlighting paradoxical reactions to IL-17 inhibition.

Front Immunol. 2025 Jul 17;16:1628461. doi: 10.3389/fimmu.2025.1628461. eCollection 2025.

Strategies for targeting cytokines in inflammatory bowel disease.

Nat Rev Immunol. 2024 Aug;24(8):559-576. doi: 10.1038/s41577-024-01008-6. Epub 2024 Mar 14.

Immune response modulation in inflammatory bowel diseases by infection.

World J Gastroenterol. 2023 Aug 14;29(30):4604-4615. doi: 10.3748/wjg.v29.i30.4604.

Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?-A Narrative Review.

J Clin Med. 2022 Oct 14;11(20):6060. doi: 10.3390/jcm11206060.

Distinct roles of interleukin-17 and T helper 17 cells among autoimmune diseases.

J Transl Autoimmun. 2021 May 25;4:100104. doi: 10.1016/j.jtauto.2021.100104. eCollection 2021.

Inflammatory versus Anti-inflammatory Profiles in Major Depressive Disorders-The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3.

J Pers Med. 2021 Jan 23;11(2):66. doi: 10.3390/jpm11020066.

IBD considerations in spondyloarthritis.

Ther Adv Musculoskelet Dis. 2020 Jul 9;12:1759720X20939410. doi: 10.1177/1759720X20939410. eCollection 2020.

IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in -Infected Mice.

Mediators Inflamm. 2019 Sep 10;2019:6750861. doi: 10.1155/2019/6750861. eCollection 2019.

T lymphocytes in the intestinal mucosa: defense and tolerance.

Cell Mol Immunol. 2019 Mar;16(3):216-224. doi: 10.1038/s41423-019-0208-2. Epub 2019 Feb 20.

Rapid Onset of Inflammatory Bowel Disease after Receiving Secukinumab Infusion.

ACG Case Rep J. 2018 Aug 1;5:e56. doi: 10.14309/crj.2018.56. eCollection 2018.

本文引用的文献

A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

Nat Immunol. 2009 Jun;10(6):603-9. doi: 10.1038/ni.1736.

Induction and effector functions of T(H)17 cells.

Nature. 2008 Jun 19;453(7198):1051-7. doi: 10.1038/nature07036.

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

Immunity. 2008 Apr;28(4):546-58. doi: 10.1016/j.immuni.2008.02.017.

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Science. 2006 Dec 1;314(5804):1461-3. doi: 10.1126/science.1135245. Epub 2006 Oct 26.

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.

Immunol Rev. 2006 Aug;212:256-71. doi: 10.1111/j.0105-2896.2006.00423.x.

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.

J Exp Med. 2006 Aug 7;203(8):2009-19. doi: 10.1084/jem.20052222. Epub 2006 Jul 31.

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

J Clin Invest. 2006 May;116(5):1310-6. doi: 10.1172/JCI21404.

The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells.

Nat Immunol. 2001 Aug;2(8):671-2. doi: 10.1038/90604.

CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease.

J Autoimmun. 1997 Oct;10(5):455-9. doi: 10.1016/s0896-8411(97)90152-9.

Interleukin-10-deficient mice develop chronic enterocolitis.

Cell. 1993 Oct 22;75(2):263-74. doi: 10.1016/0092-8674(93)80068-p.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验