Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, Israel.
Hum Brain Mapp. 2009 Nov;30(11):3687-95. doi: 10.1002/hbm.20797.
This study assesses the feasibility of using a multiperturbation analysis (MPA) approach for lesion-symptom mapping. We analyze the relative contribution of damage in different brain regions to the expression of spatial neglect, as revealed in line-bisection performance. The data set comprised of normalized lesion information and bisection test results from 23 first-event right-hemisphere stroke patients. Obtaining quantitative measures of task relevance for different regions of interest (ROIs), the following ROIs were found to be the most contributing: the supramarginal and angular gyri of the inferior parietal lobule, the superior parietal lobule, the anterior part of the temporo-parietal junction connecting the superior temporal and supramarginal gyri, and the thalamus. MPA is likely to play an important role in elucidating the anatomical substrate of complex functions.
本研究评估了使用多扰动分析（MPA）方法进行病变-症状映射的可行性。我们分析了不同脑区损伤对空间忽略表达的相对贡献，这是通过线二分测试结果揭示的。该数据集包括 23 例首次右侧半球中风患者的归一化损伤信息和二分测试结果。为了获得不同感兴趣区域（ROI）的任务相关性的定量测量，发现以下 ROI 贡献最大：下顶叶的缘上回和角回、顶叶上回、连接上颞叶和缘上回的颞顶交界处的前部，以及丘脑。MPA 可能在阐明复杂功能的解剖学基础方面发挥重要作用。
