Toba Monica N, Zavaglia Melissa, Rastelli Federica, Valabrégue Romain, Pradat-Diehl Pascale, Valero-Cabré Antoni, Hilgetag Claus C
Cerebral Dynamics, Plasticity and Rehabilitation Team, Frontlab, Brain and Spine Institute, ICM, Paris, France.
Sorbonne Universités, UPMC Paris 06, Inserm UMR S 1127, CNRS UMR 7225, F-75013, & IHU-A-ICM, Paris, France.
Hum Brain Mapp. 2017 Jul;38(7):3454-3471. doi: 10.1002/hbm.23601. Epub 2017 Apr 17.
Anatomical studies conducted in neurological conditions have developed our understanding of the causal relationships between brain lesions and their clinical consequences. The analysis of lesion patterns extended across brain networks has been particularly useful in offering new insights on brain-behavior relationships. Here we applied multiperturbation Shapley value Analysis (MSA), a multivariate method based on coalitional game theory inferring causal regional contributions to specific behavioral outcomes from the characteristic functional deficits after stroke lesions. We established the causal patterns of contributions and interactions of nodes of the attentional orienting network on the basis of lesion and behavioral data from 25 right hemisphere stroke patients tested in visuo-spatial attention tasks. We calculated the percentage of damaged voxels for five right hemisphere cortical regions contributing to attentional orienting, involving seven specific Brodmann Areas (BA): Frontal Eye Fields, (FEF-BA6), Intraparietal Sulcus (IPS-BA7), Inferior Frontal Gyrus (IFG-BA44/BA45), Temporo-Parietal Junction (TPJ-BA39/BA40), and Inferior Occipital Gyrus (IOG-BA19). We computed the MSA contributions of these seven BAs to three behavioral clinical tests (line bisection, bells cancellation, and letter cancelation). Our analyses indicated IPS as the main contributor to the attentional orienting and also revealed synergistic influences among IPS, TPJ, and IOG (for bells cancellation and line bisection) and between TPJ and IFG (for bells and letter cancellation tasks). The findings demonstrate the ability of the MSA approach to infer plausible causal contributions of relevant right hemisphere sites in poststroke visuo-spatial attention and awareness disorders. Hum Brain Mapp 38:3454-3471, 2017. © 2017 Wiley Periodicals, Inc.
针对神经疾病开展的解剖学研究，加深了我们对脑损伤与其临床后果之间因果关系的理解。对跨越脑网络的损伤模式进行分析，对于提供脑与行为关系的新见解尤其有用。在此，我们应用了多扰动夏普利值分析（MSA），这是一种基于合作博弈论的多变量方法，可从卒中损伤后的特征性功能缺陷推断特定行为结果的因果区域贡献。我们基于25名右半球卒中患者在视觉空间注意任务中的损伤和行为数据，确定了注意定向网络节点的贡献和相互作用的因果模式。我们计算了五个对注意定向有贡献的右半球皮质区域受损体素的百分比，这些区域涉及七个特定的布罗德曼区（BA）：额眼区（FEF - BA6）、顶内沟（IPS - BA7）、额下回（IFG - BA44/BA45）、颞顶交界区（TPJ - BA39/BA40）和枕下回（IOG - BA19）。我们计算了这七个BA对三项行为临床测试（直线二等分、铃声取消和字母取消）的MSA贡献。我们的分析表明，IPS是注意定向的主要贡献者，还揭示了IPS、TPJ和IOG之间（针对铃声取消和直线二等分）以及TPJ和IFG之间（针对铃声和字母取消任务）的协同影响。这些发现证明了MSA方法能够推断卒中后视觉空间注意和意识障碍中相关右半球部位的合理因果贡献。《人类大脑图谱》38:3454 - 3471, 2017。© 2017威利期刊公司
